【特徴】主な研究分野例：Cancer, Cardiovascular, Metabolism, Immunology, Signaling transduction背景：TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.【仕様】抗体タイプ：ポリクローナル 抗体アプリケーション：WB,IHC交差性：Human,Mouse,Rat宿主：Rabbitアイソタイプ：IgG濃度：2 mg/mL抗原：Recombinant Human Tumor necrosis factor alpha protein緩衝液：PBS with 0.02％ sodium azide and 50％ glycerol pH 7.4.精製方法：Affinity purification希釈倍率：WB 1：500-1：1000, IHC 1：50-1：100標識：Unconjugatedクローナリティ：Polyclonalメーカーマニュアルリンク：https://www.elabscience.com/viewpdf-26196-Elabscience-E-AB-40015.pdfサイズ：60uLこの商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）